Age and sex shape cancer immunity, mouse experiments and human data suggest

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A study combining mouse experiments and human data examines how age and biological sex affect cancer immunity. The findings link age-related contraction of lymph nodes and declines in naive CD8 T cells to impaired antigen recognition, with potential implications for immunotherapy.

A new study published in Nature Aging combines mouse experiments and human data sets to explore how biological sex and aging shape cancer immunity, with implications for immunotherapy responses. Lutz Menzel, Ph.D., formerly of the Department of Radiation Oncology within the Mass General Brigham Cancer Institute, is the lead author, and Tim Padera, Ph.D., of the Mass General Brigham Cancer Institute, is the senior author. The paper is titled "Lymph node contraction links sex-biased naive CD8 T cell decline to compromised antigen recognition during middle age."