Study finds that genetic risk does not explain the maternal effect in type 1 diabetes

AI Summary

A study found that inherited genetic risk does not explain why children of mothers with type 1 diabetes develop the condition at a higher rate than children of fathers with the disease. Researchers say other biological mechanisms may contribute and require further investigation.

Children whose mothers have type 1 diabetes develop the disease at about half the rate of children whose fathers have it. Inherited genetic risk alone does not explain this long-observed maternal effect, according to a study led by researchers at the University of Colorado Anschutz and published in Diabetes Care. The findings point to other possible biological mechanisms that warrant further investigation.