RNA-triggered cell killing with CRISPR–Cas12a2

AI Summary

A study demonstrates that a specific type of CRISPR can enable targeted destruction of cells, furthering applications in genetic engineering and treatment possibilities. This discovery showcases the versatility of CRISPR technology.

Here we show that Cas12a2, a recently discovered type V CRISPR nuclease, exhibits RNA-triggered DNA shredding, and enables programmable and ...