[Review] Advancing the relevance of clinical trials for older patients

AI Summary

Older patients are the fastest growing demographic in clinical care, yet clinical trial evidence guiding their treatment is limited. Advances focus on representative patient selection, appropriate therapy choice, and relevant outcome study to improve trial relevance for older populations.

Older patients represent the fastest growing patient group in clinical care. They are a heterogeneous group, for whom evidence for making treatment decisions is often scarce. Important domains for advancing the relevance of clinical trials for older patients are selection and inclusion of representative patients, choosing appropriate therapeutic interventions, and studying relevant outcomes. In the last decade, a myriad of publications has recommended multiple solutions that improve the relevance of trials for older people.