Poor antibody validation wastes millions of biological samples, but solutions exist

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Researchers say failure to validate antibodies before using them can lead to avoidable waste of millions of human and animal tissue samples. An international expert panel has agreed on recommendations to improve validation, in studies published in PLOS Biology.

A widespread failure to validate research antibodies before use is estimated to lead to the avoidable waste of millions of animal and human tissue samples worldwide, and an international expert panel has reached consensus on how to address the problem, according to two studies published in the open-access journal PLOS Biology by Harvinder Virk of the University of Leicester, U.K., and colleagues.