New study helps explain how endometriosis causes pain

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Yale researchers report findings that may explain why endometriosis pain varies widely between patients and does not necessarily correspond to the extent of visible disease. Some patients with few growths experience severe pain, while others with more extensive disease have no symptoms.

One of the puzzling aspects of endometriosis—a gynecologic condition in which tissue similar to that lining the uterus grows outside of it—is that the extent of the disease doesn't determine the severity of its symptoms. New Yale research may help explain why some patients with a small number of growths experience debilitating pain, while others with more widespread disease have no symptoms.