Model reveals strategies to modify the tumor microenvironment and improve cancer therapy

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Researchers from Mass General Brigham and the University of Cyprus developed a mathematical model examining how the tumor microenvironment affects delivery and effectiveness of immunomodulatory antibody-drug conjugates. The findings may help guide strategies to improve cancer therapy.

Researchers from Mass General Brigham and the University of Cyprus have developed a mathematical model to better understand how the tumor microenvironment affects the delivery and effectiveness of a new type of cancer therapy called an immunomodulatory antibody-drug conjugate (IM-ADC). The work is published in the Journal for ImmunoTherapy of Cancer.