Intracellular mechanisms promote tumor survival during hypoxia

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Northwestern Medicine researchers have identified the intracellular mechanisms governing rapid gene expression changes under hypoxia, a common condition in treatment-resistant tumors. This discovery could advance understanding of tumor survival and aid therapeutic development.

Northwestern Medicine scientists have, for the first time, described the underlying mechanisms that regulate how cells rapidly change gene expression in response to hypoxia, a key feature of many treatment-resistant tumors, according to a recent study published in Science Advances.