High-salt diet may drive fatty liver disease differently in lean people

AI Summary

Scientists at Duke-NUS Medical School found in a mouse model that excess dietary salt may alter liver metabolism and trigger inflammatory pathways linked to fatty liver disease in lean people. The findings may help explain lean metabolic dysfunction-associated steatohepatitis, a condition not typically associated with obesity.

Fatty liver disease is commonly associated with obesity, yet a growing number of people with normal body weight develop a severe form of the condition. Scientists at Duke-NUS Medical School have identified a distinct mechanism in a mouse model that may help explain why: Excess dietary salt can alter liver metabolism and trigger inflammatory pathways associated with lean metabolic dysfunction-associated steatohepatitis (MASH).