High-fat diet activates cellular repair pathway that helps colon cancer spread

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MIT biologists have identified a cellular pathway activated by a high-fat diet that facilitates the spread of colon cancer cells beyond the colon, often to the liver. This discovery sheds light on mechanisms driving colorectal cancer metastasis and potential therapeutic targets.

Most colon cancer deaths are caused by the spread of tumor cells beyond the colon, usually to the liver. In a new study, MIT biologists identified a cellular pathway necessary for colorectal cancer metastasis.