Faulty calcium signaling may drive dry mouth in Down syndrome, raising gum disease risk

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Researchers at NYU College of Dentistry have identified a defective calcium signaling mechanism that may cause dry mouth and increase gum disease risk in individuals with Down syndrome, according to a study published in Cell Reports. This molecular insight sheds light on unique oral health challenges faced by this population.

Researchers at NYU College of Dentistry have uncovered what may be biologically driving oral health issues unique to Down syndrome. Their study, published in Cell Reports, describes a molecular mechanism—a defect in calcium signaling—behind low saliva production, along with other factors that may contribute to gum disease.