Discovering a new layer of control for a decades-old leukemia drug

AI Summary

Research is uncovering new molecular mechanisms by which the longstanding leukemia drug 6-thioguanine affects cancer cells. These findings deepen understanding of how the drug induces cell death or survival in leukemia treatment, potentially improving therapeutic applications.

For more than 70 years, the drug 6-thioguanine (6-TG) has been used to treat leukemia. Although its clinical effects have been studied extensively, scientists are still uncovering the molecular mechanisms that determine whether cells succumb to the drug or survive its attack.