Blood RNA signal may reveal ovarian cancer precursors before invasive disease develops

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Researchers at Hoag report a blood RNA signal that may identify serous tubal intraepithelial carcinoma, a precancerous stage associated with high-grade serous ovarian cancer. Detecting this signal could help identify disease before it becomes invasive, addressing the tendency for ovarian cancer to be diagnosed late.

Hoag researchers have discovered a molecular warning signal in the blood that identifies serous tubal intraepithelial carcinoma (STIC), an early, precancerous stage of high-grade serous ovarian cancer (HGSOC). This advance is particularly significant because ovarian cancer is often diagnosed at an advanced stage, after the disease has already spread.