Blood cells from 80-year-old donor become stem cells with molecular age under 20

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Researchers at the University Hospital of Bonn and the University of Bonn reprogrammed human blood-cell precursors into stem cells in a laboratory. The process reset molecular aging indicators, producing stem cells from an 80-year-old donor with a measured molecular age under 20.

Researchers from the University Hospital of Bonn and the University of Bonn have succeeded in dramatically rejuvenating human cells in a test tube. To do so, they directly reprogrammed red blood cell precursors into stem cells from which neurons can be derived. During this process, the molecular clocks that indicate a cell's age were reset. For example, blood cells from an 80-year-old were transformed into stem cells with a molecular age of less than 20 years.