Alzheimer’s may have early warning signs outside the brain

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Researchers using human-cell laboratory models found that genetic mutations linked to inherited Alzheimer’s can disrupt nerve-to-muscle connections even without the brain or spinal cord. The finding may help explain why balance, walking, and coordination changes can appear before memory symptoms.

A surprising discovery suggests that some early signs of Alzheimer’s disease may begin outside the brain. Using miniature laboratory systems made from human cells, scientists found that genetic mutations associated with inherited Alzheimer’s can disrupt nerve-to-muscle connections without any involvement from the brain or spinal cord. This could help explain why some patients experience changes in balance, walking, and coordination long before memory problems develop.