AI-guided CRISPR uncovers oxytocin receptor as unexpected psoriasis drug target

AI Summary

Researchers at Biohub conducted a genome-wide CRISPR study on human skin cells using AI to identify novel drug targets for psoriasis, discovering the oxytocin receptor as an unexpected candidate. This innovative AI-guided biomedical research opens new avenues for psoriasis treatment.

Biohub researchers have performed what they believe is the first genome-wide CRISPR study of primary human adult skin cells, then used an AI model to mine the results for overlooked drug targets for psoriasis. They found an unlikely candidate: the receptor for oxytocin, a hormone involved in childbirth and sometimes called the "love hormone" for its additional role in social bonding.